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Clinicaltrials.gov was looked for registered research protocols. The key phrases “palmitoylethanolamide” and “pain” resulted in 13 entries, of which three have been accomplished. None of them fulfilled our eligibility standards.This can be of great importance with respect on the catabolism of exogenous PEA if fatty acid binding proteins Per
2015). These scientific studies, taken alongside one another, counsel that, Despite the fact that a immediate activation of GPR55 or PPAR‐α takes place, PEA can generate its anti‐inflammatory action inside the gut also via oblique activation of CB1 and CB2 receptors, possibly due to the ability of the compound to potentiate the action of endoc
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2016a). This smaller increase was proportionate on the scaled-down peak of PEA degrees detected in human volunteers compared with beagle canines. This variation, consequently, is often due to the decrease full number of PEA acutely administered to human volunteers (about ∼five vs. thirty mg·kg−1 in canines) and also to The truth that this was